I suggest the occurrence of many diseases is dependent upon the decline of DHEA which begins around 20-25 years of age and reaches very low levels in old age. Also, it follows from my work, that many problems that are increasing with time in the United States and in the world are resulting from the "secular trend," which I suggest is due to the increase in percentages of individuals of higher testosterone and the negative effect that testosterone exerts on the availability of DHEA. Disturbances in "dehydroepiandrosterone homeostasis" may be a significant source of morbidity and mortality.
(Copyright 2003, James Michael Howard, Fayetteville, Arkansas, U.S.A.)
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